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  • F
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  • OMOE
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碱基类型
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  • UNA
  • RNA
  • DNA
  • LNA
糖修饰
  • Others
  • CN
  • CH3
  • F
  • OCH3
  • OMOE
  • OH
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010-52073088
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天然存在的小核酸具有较差的稳定性和非常低的特异性,化学修饰是增强小核苷酸药物成药的有效方法。除了小核酸的磷酸骨架的PS修饰,大多数是在核苷的核糖和碱基的修饰已被广泛采用。将修饰的好的核苷和磷试剂反应做成核酸单体(亚磷酰胺结构),核酸单体按照序列进行小核酸药物的组装。

Base R A C meC G T U I
H 958-09-8
958-09-8

958-09-8

C10H13N5O3 251.25

951-77-9
951-77-9

951-77-9

C9H13N3O4 227.22

838-07-3
838-07-3

838-07-3

C10H15N3O4 241.25

961-07-9
961-07-9

961-07-9

C10H13N5O4 267.25

50-89-5
50-89-5

50-89-5

C10H14N2O5 242.23

951-78-0
951-78-0

951-78-0

C9H12N2O5 228.2

890-38-0
890-38-0

890-38-0

C10H12N4O4 252.23

F 64183-27-3
64183-27-3

64183-27-3

C10H12FN5O3 269.24

10212-20-1
10212-20-1

10212-20-1

C9H12FN3O4 245.21

182495-80-3
182495-80-3

182495-80-3

C10H14FN3O4 259.24

78842-13-4
78842-13-4

78842-13-4

C10H13FN2O5 260.22

122799-38-6
122799-38-6

122799-38-6

C10H13FN2O5 260.22

784-71-4
784-71-4

784-71-4

C9H11FN2O5 246.19

无登记
无登记

无登记

C10H11FN4O4 270.22

OCH3 2140-79-6
2140-79-6

2140-79-6

C11H15N5O4 281.27

2140-72-9
2140-72-9

2140-72-9

C10H15N3O5 257.25

113886-70-7
113886-70-7

113886-70-7

C11H17N3O5 271.27

2140-71-8
2140-71-8

2140-71-8

C11H15N5O5 297.27

55486-09-4
55486-09-4

55486-09-4

C11H16N2O6 272.26

2140-76-3
2140-76-3

2140-76-3

C10H14N2O6 258.23

无登记
无登记

无登记

C11H14N4O5 282.26

OMOE 168427-74-5
168427-74-5

168427-74-5

C13H19N5O5 325.33

223777-16-0
223777-16-0

223777-16-0

C12H19N3O6 301.3

244105-55-3
244105-55-3

244105-55-3

C13H21N3O6 315.33

473278-54-5
473278-54-5

473278-54-5

C13H19N5O6 341.32

163759-49-7
163759-49-7

163759-49-7

C13H20N2O7 316.31

223777-15-9
223777-15-9

223777-15-9

C12H18N2O7 302.28

无登记
无登记

无登记

C13H18N4O6 326.31

OC16H33 211690-85-6
211690-85-6

211690-85-6

C26H45N5O4 491.68

2991498-23-6
2991498-23-6

2991498-23-6

C25H45N3O5 467.65

无登记
无登记

无登记

C26H47N3O5 481.68

2382942-29-0
2382942-29-0

2382942-29-0

C26H45N5O5 507.68

2991498-24-7
2991498-24-7

2991498-24-7

C26H46N2O6 482.66

2382942-69-8
2382942-69-8

2382942-69-8

C25H44N2O6 468.64

无登记
无登记

无登记

C26H44N4O5 492.66

OPA 151390-97-5
151390-97-5

151390-97-5

C14H19N5O4 321.34

206552-85-4
206552-85-4

206552-85-4

C12H15N3O5 281.27

无登记
无登记

无登记

C14H21N3O5 311.34

206552-86-5
206552-86-5

206552-86-5

C14H19N5O5 337.34

860640-50-2
860640-50-2

860640-50-2

C14H20N2O6 312.32

129778-58-1
129778-58-1

129778-58-1

C12H14N2O6 282.25

无登记
无登记

无登记

C14H18N4O5 322.32

其他 定制
Base R A meC G T
H 206055-70-1
206055-70-1

206055-70-1

C11H13N5O4 279.26

847650-87-7
847650-87-7

847650-87-7

C11H15N3O5 269.26

207131-16-6
207131-16-6

207131-16-6

C11H13N5O5 295.26

206055-67-6
206055-67-6

206055-67-6

C11H14N2O6 270.24

CH3 1197033-34-3
1197033-34-3

1197033-34-3

C12H15N5O4 293.28

1197033-37-6
1197033-37-6

1197033-37-6

C12H17N3O5 283.28

1197033-35-4
1197033-35-4

1197033-35-4

C12H15N5O5 309.28

1197032-96-4
1197032-96-4

1197032-96-4

C12H16N2O6 284.27

CN 无登记
无登记

无登记

C12H12N6O4 304.27

无登记
无登记

无登记

C12H14N4O5 294.27

无登记
无登记

无登记

C12H12N6O5 320.27

2404654-10-8
2404654-10-8

2404654-10-8

C12H13N3O6 295.25

其他 定制
Base R A(Bz) C(Bz) C(Ac) meC(Bz) G(iBu) G(dmf)
H 4546-72-9
4546-72-9

4546-72-9

C17H17N5O4 355.35

4836-13-9
4836-13-9

4836-13-9

C16H17N3O5 331.33

32909-05-0
32909-05-0

32909-05-0

C11H15N3O5 269.26

104579-02-4
104579-02-4

104579-02-4

C17H19N3O5 345.36

68892-42-2
68892-42-2

68892-42-2

C14H19N5O5 337.34

17331-13-4
17331-13-4

17331-13-4

C13H18N6O4 322.33

F 136834-20-3
136834-20-3

136834-20-3

C17H16FN5O4 373.34

146954-76-9
146954-76-9

146954-76-9

C16H16FN3O5 349.32

159414-97-8
159414-97-8

159414-97-8

C11H14FN3O5 287.25

182495-81-4
182495-81-4

182495-81-4

C17H18FN3O5 363.35

80681-25-0
80681-25-0

80681-25-0

C14H18FN5O5 355.33

无登记
无登记

无登记

C13H17FN6O4 340.32

OCH3 85079-00-1
85079-00-1

85079-00-1

C18H19N5O5 385.38

52571-45-6
52571-45-6

52571-45-6

C17H19N3O6 361.35

113886-71-8
113886-71-8

113886-71-8

C12H17N3O6 299.28

158966-50-8
158966-50-8

158966-50-8

C18H21N3O6 375.38

63264-29-9
63264-29-9

63264-29-9

C15H21N5O6 367.36

1951424-87-5
1951424-87-5

1951424-87-5

C14H20N6O5 352.35

OMOE 333335-93-6
333335-93-6

333335-93-6

C20H23N5O6 429.43

2305416-18-4
2305416-18-4

2305416-18-4

C19H23N3O7 405.41

2049081-09-4
2049081-09-4

2049081-09-4

C14H21N3O7 343.34

340162-93-8
340162-93-8

340162-93-8

C20H25N3O7 419.43

440327-50-4
440327-50-4

440327-50-4

C17H25N5O7 411.42

无登记
无登记

无登记

C16H24N6O6 396.4

OH 4546-55-8
4546-55-8

4546-55-8

C17H17N5O5 371.35

13089-48-0
13089-48-0

13089-48-0

C16H17N3O6 347.33

3768-18-1
3768-18-1

3768-18-1

C11H15N3O6 285.26

160107-15-3
160107-15-3

160107-15-3

C17H19N3O6 361.35

64350-24-9
64350-24-9

64350-24-9

C14H19N5O6 353.34

1055407-32-3
1055407-32-3

1055407-32-3

C13H18N6O5 338.32

OC16H33 2382942-33-6
2382942-33-6

2382942-33-6

C33H49N5O5 595.79

无登记
无登记

无登记

C32H49N3O6 571.76

无登记
无登记

无登记

C27H47N3O6 509.69

无登记
无登记

无登记

C33H51N3O6 585.79

2382942-30-3
2382942-30-3

2382942-30-3

C30H51N5O6 577.77

无登记
无登记

无登记

C29H50N6O5 562.76

OPA 210096-44-9
210096-44-9

210096-44-9

C20H19N5O5 409.4

210096-41-6
210096-41-6

210096-41-6

C19H19N3O6 385.38

1498305-49-9
1498305-49-9

1498305-49-9

C14H17N3O6 323.31

无登记
无登记

无登记

C20H21N3O6 399.4

2095417-55-1
2095417-55-1

2095417-55-1

C17H21N5O6 391.38

197151-26-1
197151-26-1

197151-26-1

C16H20N6O5 376.37

OPOM 2842847-62-3
2842847-62-3

2842847-62-3

C23H27N5O7 485.5

无登记
无登记

无登记

C22H27N3O8 461.47

无登记
无登记

无登记

C17H25N3O8 399.4

无登记
无登记

无登记

C23H29N3O8 475.5

无登记
无登记

无登记

C20H29N5O8 467.48

无登记
无登记

无登记

C19H28N6O7 452.47

其他 定制
Base R A(Bz) meC(Bz) G(iBu)
H 209968-94-5
209968-94-5

209968-94-5

C18H17N5O5 383.36

206055-81-4
206055-81-4

206055-81-4

C18H19N3O6 373.37

206055-68-7
206055-68-7

206055-68-7

C15H21N5O5 351.36

CH3 1197033-12-7
1197033-12-7

1197033-12-7

C19H19N5O5 397.39

1197033-07-0
1197033-07-0

1197033-07-0

C19H21N3O6 387.39

945628-64-8
945628-64-8

945628-64-8

C16H23N5O5 365.39

CN 无登记
无登记

无登记

C19H16N6O5 406.4

无登记
无登记

无登记

C19H18N4O6 396.4

无登记
无登记

无登记

C16H20N6O5 374.4

其他 定制
Base R A(Bz) C(Bz) C(Ac) meC(Bz) G(iBu) G(dmf) T U
H 64325-78-6
64325-78-6

64325-78-6

C38H35N5O6 657.73

67219-55-0
67219-55-0

67219-55-0

C37H35N3O7 33.7

100898-63-3
100898-63-3

100898-63-3

C32H33N3O7 571.63

104579-03-5
104579-03-5

104579-03-5

C38H37N3O7 647.73

68892-41-1
68892-41-1

68892-41-1

C35H37N5O7 639.71

40094-22-2
40094-22-2

40094-22-2

C34H36N6O6 624.7

40615-39-2
40615-39-2

40615-39-2

C31H32N2O7 544.6

23669-79-6
23669-79-6

23669-79-6

C30H30N2O7 530.58

F 136834-21-4
136834-21-4

136834-21-4

C38H34FN5O6 675.72

146954-77-0
146954-77-0

146954-77-0

C37H34FN3O7 651.69

159414-98-9
159414-98-9

159414-98-9

C32H32FN3O7 589.62

182495-82-5
182495-82-5

182495-82-5

C38H36FN3O7 665.72

144089-96-3
144089-96-3

144089-96-3

C35H36FN5O7 657.7

2377586-41-7
2377586-41-7

2377586-41-7

C34H35FN6O6 642.69

133324-02-4
133324-02-4

133324-02-4

C31H31FN2O7 562.59

146954-74-4
146954-74-4

146954-74-4

C30H29FN2O7 548.57

OCH3 110764-72-2
110764-72-2

110764-72-2

C39H37N5O7 687.75

110764-74-4
110764-74-4

110764-74-4

C38H37N3O8 663.73

199593-08-3
199593-08-3

199593-08-3

C33H35N3O8 601.66

741725-57-5
741725-57-5

741725-57-5

C39H39N3O8 677.75

114745-26-5
114745-26-5

114745-26-5

C36H39N5O8 669.74

1858223-91-2
1858223-91-2

1858223-91-2

C35H38N6O7 654.72

153631-19-7
153631-19-7

153631-19-7

C32H34N2O8 574.63

103285-22-9
103285-22-9

103285-22-9

C31H32N2O8 560.6

OMOE 251647-48-0
251647-48-0

251647-48-0

C41H41N5O8 731.81

251647-49-1
251647-49-1

251647-49-1

C40H41N3O9 707.78

1345716-47-3
1345716-47-3

1345716-47-3

C35H39N3O9 645.71

182496-01-1
182496-01-1

182496-01-1

C41H43N3O9 721.81

251647-50-4
251647-50-4

251647-50-4

C38H43N5O9 713.79

无登记
无登记

无登记

C37H42N6O8 698.78

163759-50-0
163759-50-0

163759-50-0

C34H38N2O9 618.68

251647-51-5
251647-51-5

251647-51-5

C33H36N2O9 604.66

OH 81246-82-4
81246-82-4

81246-82-4

C38H35N5O7 673.73

81246-76-6
81246-76-6

81246-76-6

C37H35N3O8 649.7

121058-82-0
121058-82-0

121058-82-0

C32H33N3O8 587.63

160107-17-5
160107-17-5

160107-17-5

C38H37N3O8 663.73

81246-83-5
81246-83-5

81246-83-5

C35H37N5O8 655.71

126922-60-9
126922-60-9

126922-60-9

C34H36N6O7 640.7

138239-62-0
138239-62-0

138239-62-0

C31H32N2O8 560.6

81246-79-9
81246-79-9

81246-79-9

C30H30N2O8 546.58

OTBS 81265-93-2
81265-93-2

81265-93-2

C44H49N5O7Si 787.99

81256-87-3
81256-87-3

81256-87-3

C43H49N3O8Si 763.96

121058-85-3
121058-85-3

121058-85-3

C38H47N3O8Si 701.89

160107-13-1
160107-13-1

160107-13-1

C44H51N3O8Si 777.99

81279-39-2
81279-39-2

81279-39-2

C41H51N5O8Si 769.97

126922-61-0
126922-61-0

126922-61-0

C40H50N6O7Si 754.96

145784-40-3
145784-40-3

145784-40-3

C37H46N2O8Si 674.87

81246-80-2
81246-80-2

81246-80-2

C36H44N2O8Si 660.84

OC16H33 2382942-34-7
2382942-34-7

2382942-34-7

C54H67N5O7 898.16

无登记
无登记

无登记

C53H67N3O8 874.13

2382942-37-0
2382942-37-0

2382942-37-0

C48H65N3O8 812.06

无登记
无登记

无登记

C54H69N3O8 888.16

2382942-31-4
2382942-31-4

2382942-31-4

C51H69N5O8 880.14

无登记
无登记

无登记

C50H68N6O7 865.13

无登记
无登记

无登记

C47H64N2O8 785.04

2382942-76-7
2382942-76-7

2382942-76-7

C46H62N2O8 771.01

OPA 171486-51-4
171486-51-4

171486-51-4

C41H37N5O7 711.78

171486-52-5
171486-52-5

171486-52-5

C40H37N3O8 687.75

1498305-50-2
1498305-50-2

1498305-50-2

C35H35N3O8 625.68

无登记
无登记

无登记

C41H39N3O8 701.78

171486-53-6
171486-53-6

171486-53-6

C38H39N5O8 693.76

210096-45-0
210096-45-0

210096-45-0

C37H38N6O7 678.75

860640-56-8
860640-56-8

860640-56-8

C34H34N2O8 598.65

171486-54-7
171486-54-7

171486-54-7

C33H32N2O8 584.63

其他 定制
Base R A(Bz) C(Ac) G(iBu) U
OH 1044505-21-6
1044505-21-6

1044505-21-6

C41H37N5O7 711.78

1120329-54-5
1120329-54-5

1120329-54-5

C40H37N3O8 687.75

1044505-27-2
1044505-27-2

1044505-27-2

C35H35N3O8 625.68

251943-33-6
251943-33-6

251943-33-6

C41H39N3O8 701.78

OBz 1120329-51-2
1120329-51-2

1120329-51-2

C41H37N5O7 711.78

120329-55-6
120329-55-6

120329-55-6

C40H37N3O8 687.75

1120329-60-3
1120329-60-3

1120329-60-3

C35H35N3O8 625.68

251943-34-7
251943-34-7

251943-34-7

C41H39N3O8 701.78

其他 定制
Base R A(Bz) meC(Bz) G(iBu)
H 206055-74-5
206055-74-5

206055-74-5

C39H35N5O7 685.74

445012-77-1
445012-77-1

445012-77-1

C39H37N3O8 675.74

206055-72-3
206055-72-3

206055-72-3

C36H39N5O7 653.74

CH3 1197033-18-3
1197033-18-3

1197033-18-3

C40H37N5O7 699.76

1197033-15-0
1197033-15-0

1197033-15-0

C40H39N3O8 689.77

945628-65-9
945628-65-9

945628-65-9

C37H41N5O7 667.76

CN 无登记
无登记

无登记

C40H34N6O7 710.75

无登记
无登记

无登记

C41H38N4O7 698.78

无登记
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C37H38N6O7 678.75

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