天然存在的小核酸具有较差的稳定性和非常低的特异性,化学修饰是增强小核苷酸药物成药的有效方法。除了小核酸的磷酸骨架的PS修饰,大多数是在核苷的核糖和碱基的修饰已被广泛采用。将修饰的好的核苷和磷试剂反应做成核酸单体(亚磷酰胺结构),核酸单体按照序列进行小核酸药物的组装。
Base R | A | C | meC | G | T | U | I |
---|---|---|---|---|---|---|---|
H |
958-09-8
958-09-8C10H13N5O3 251.25 |
951-77-9
951-77-9C9H13N3O4 227.22 |
838-07-3
838-07-3C10H15N3O4 241.25 |
961-07-9
961-07-9C10H13N5O4 267.25 |
50-89-5
50-89-5C10H14N2O5 242.23 |
951-78-0
951-78-0C9H12N2O5 228.2 |
890-38-0
890-38-0C10H12N4O4 252.23 |
F |
64183-27-3
64183-27-3C10H12FN5O3 269.24 |
10212-20-1
10212-20-1C9H12FN3O4 245.21 |
182495-80-3
182495-80-3C10H14FN3O4 259.24 |
78842-13-4
78842-13-4C10H13FN2O5 260.22 |
122799-38-6
122799-38-6C10H13FN2O5 260.22 |
784-71-4
784-71-4C9H11FN2O5 246.19 |
无登记
无登记C10H11FN4O4 270.22 |
OCH3 |
2140-79-6
2140-79-6C11H15N5O4 281.27 |
2140-72-9
2140-72-9C10H15N3O5 257.25 |
113886-70-7
113886-70-7C11H17N3O5 271.27 |
2140-71-8
2140-71-8C11H15N5O5 297.27 |
55486-09-4
55486-09-4C11H16N2O6 272.26 |
2140-76-3
2140-76-3C10H14N2O6 258.23 |
无登记
无登记C11H14N4O5 282.26 |
OMOE |
168427-74-5
168427-74-5C13H19N5O5 325.33 |
223777-16-0
223777-16-0C12H19N3O6 301.3 |
244105-55-3
244105-55-3C13H21N3O6 315.33 |
473278-54-5
473278-54-5C13H19N5O6 341.32 |
163759-49-7
163759-49-7C13H20N2O7 316.31 |
223777-15-9
223777-15-9C12H18N2O7 302.28 |
无登记
无登记C13H18N4O6 326.31 |
OC16H33 |
211690-85-6
211690-85-6C26H45N5O4 491.68 |
2991498-23-6
2991498-23-6C25H45N3O5 467.65 |
无登记
无登记C26H47N3O5 481.68 |
2382942-29-0
2382942-29-0C26H45N5O5 507.68 |
2991498-24-7
2991498-24-7C26H46N2O6 482.66 |
2382942-69-8
2382942-69-8C25H44N2O6 468.64 |
无登记
无登记C26H44N4O5 492.66 |
OPA |
151390-97-5
151390-97-5C14H19N5O4 321.34 |
206552-85-4
206552-85-4C12H15N3O5 281.27 |
无登记
无登记C14H21N3O5 311.34 |
206552-86-5
206552-86-5C14H19N5O5 337.34 |
860640-50-2
860640-50-2C14H20N2O6 312.32 |
129778-58-1
129778-58-1C12H14N2O6 282.25 |
无登记
无登记C14H18N4O5 322.32 |
其他 | 定制 |
Base R | A | meC | G | T |
---|---|---|---|---|
H |
206055-70-1
206055-70-1C11H13N5O4 279.26 |
847650-87-7
847650-87-7C11H15N3O5 269.26 |
207131-16-6
207131-16-6C11H13N5O5 295.26 |
206055-67-6
206055-67-6C11H14N2O6 270.24 |
CH3 |
1197033-34-3
1197033-34-3C12H15N5O4 293.28 |
1197033-37-6
1197033-37-6C12H17N3O5 283.28 |
1197033-35-4
1197033-35-4C12H15N5O5 309.28 |
1197032-96-4
1197032-96-4C12H16N2O6 284.27 |
CN |
无登记
无登记C12H12N6O4 304.27 |
无登记
无登记C12H14N4O5 294.27 |
无登记
无登记C12H12N6O5 320.27 |
2404654-10-8
2404654-10-8C12H13N3O6 295.25 |
其他 | 定制 |
Base R | A(Bz) | C(Bz) | C(Ac) | meC(Bz) | G(iBu) | G(dmf) |
---|---|---|---|---|---|---|
H |
4546-72-9
4546-72-9C17H17N5O4 355.35 |
4836-13-9
4836-13-9C16H17N3O5 331.33 |
32909-05-0
32909-05-0C11H15N3O5 269.26 |
104579-02-4
104579-02-4C17H19N3O5 345.36 |
68892-42-2
68892-42-2C14H19N5O5 337.34 |
17331-13-4
17331-13-4C13H18N6O4 322.33 |
F |
136834-20-3
136834-20-3C17H16FN5O4 373.34 |
146954-76-9
146954-76-9C16H16FN3O5 349.32 |
159414-97-8
159414-97-8C11H14FN3O5 287.25 |
182495-81-4
182495-81-4C17H18FN3O5 363.35 |
80681-25-0
80681-25-0C14H18FN5O5 355.33 |
无登记
无登记C13H17FN6O4 340.32 |
OCH3 |
85079-00-1
85079-00-1C18H19N5O5 385.38 |
52571-45-6
52571-45-6C17H19N3O6 361.35 |
113886-71-8
113886-71-8C12H17N3O6 299.28 |
158966-50-8
158966-50-8C18H21N3O6 375.38 |
63264-29-9
63264-29-9C15H21N5O6 367.36 |
1951424-87-5
1951424-87-5C14H20N6O5 352.35 |
OMOE |
333335-93-6
333335-93-6C20H23N5O6 429.43 |
2305416-18-4
2305416-18-4C19H23N3O7 405.41 |
2049081-09-4
2049081-09-4C14H21N3O7 343.34 |
340162-93-8
340162-93-8C20H25N3O7 419.43 |
440327-50-4
440327-50-4C17H25N5O7 411.42 |
无登记
无登记C16H24N6O6 396.4 |
OH |
4546-55-8
4546-55-8C17H17N5O5 371.35 |
13089-48-0
13089-48-0C16H17N3O6 347.33 |
3768-18-1
3768-18-1C11H15N3O6 285.26 |
160107-15-3
160107-15-3C17H19N3O6 361.35 |
64350-24-9
64350-24-9C14H19N5O6 353.34 |
1055407-32-3
1055407-32-3C13H18N6O5 338.32 |
OC16H33 |
2382942-33-6
2382942-33-6C33H49N5O5 595.79 |
无登记
无登记C32H49N3O6 571.76 |
无登记
无登记C27H47N3O6 509.69 |
无登记
无登记C33H51N3O6 585.79 |
2382942-30-3
2382942-30-3C30H51N5O6 577.77 |
无登记
无登记C29H50N6O5 562.76 |
OPA |
210096-44-9
210096-44-9C20H19N5O5 409.4 |
210096-41-6
210096-41-6C19H19N3O6 385.38 |
1498305-49-9
1498305-49-9C14H17N3O6 323.31 |
无登记
无登记C20H21N3O6 399.4 |
2095417-55-1
2095417-55-1C17H21N5O6 391.38 |
197151-26-1
197151-26-1C16H20N6O5 376.37 |
OPOM |
2842847-62-3
2842847-62-3C23H27N5O7 485.5 |
无登记
无登记C22H27N3O8 461.47 |
无登记
无登记C17H25N3O8 399.4 |
无登记
无登记C23H29N3O8 475.5 |
无登记
无登记C20H29N5O8 467.48 |
无登记
无登记C19H28N6O7 452.47 |
其他 | 定制 |
Base R | A(Bz) | meC(Bz) | G(iBu) |
---|---|---|---|
H |
209968-94-5
209968-94-5C18H17N5O5 383.36 |
206055-81-4
206055-81-4C18H19N3O6 373.37 |
206055-68-7
206055-68-7C15H21N5O5 351.36 |
CH3 |
1197033-12-7
1197033-12-7C19H19N5O5 397.39 |
1197033-07-0
1197033-07-0C19H21N3O6 387.39 |
945628-64-8
945628-64-8C16H23N5O5 365.39 |
CN |
无登记
无登记C19H16N6O5 406.4 |
无登记
无登记C19H18N4O6 396.4 |
无登记
无登记C16H20N6O5 374.4 |
其他 | 定制 |
Base R | A(Bz) | C(Bz) | C(Ac) | meC(Bz) | G(iBu) | G(dmf) | T | U |
---|---|---|---|---|---|---|---|---|
H |
64325-78-6
64325-78-6C38H35N5O6 657.73 |
67219-55-0
67219-55-0C37H35N3O7 33.7 |
100898-63-3
100898-63-3C32H33N3O7 571.63 |
104579-03-5
104579-03-5C38H37N3O7 647.73 |
68892-41-1
68892-41-1C35H37N5O7 639.71 |
40094-22-2
40094-22-2C34H36N6O6 624.7 |
40615-39-2
40615-39-2C31H32N2O7 544.6 |
23669-79-6
23669-79-6C30H30N2O7 530.58 |
F |
136834-21-4
136834-21-4C38H34FN5O6 675.72 |
146954-77-0
146954-77-0C37H34FN3O7 651.69 |
159414-98-9
159414-98-9C32H32FN3O7 589.62 |
182495-82-5
182495-82-5C38H36FN3O7 665.72 |
144089-96-3
144089-96-3C35H36FN5O7 657.7 |
2377586-41-7
2377586-41-7C34H35FN6O6 642.69 |
133324-02-4
133324-02-4C31H31FN2O7 562.59 |
146954-74-4
146954-74-4C30H29FN2O7 548.57 |
OCH3 |
110764-72-2
110764-72-2C39H37N5O7 687.75 |
110764-74-4
110764-74-4C38H37N3O8 663.73 |
199593-08-3
199593-08-3C33H35N3O8 601.66 |
741725-57-5
741725-57-5C39H39N3O8 677.75 |
114745-26-5
114745-26-5C36H39N5O8 669.74 |
1858223-91-2
1858223-91-2C35H38N6O7 654.72 |
153631-19-7
153631-19-7C32H34N2O8 574.63 |
103285-22-9
103285-22-9C31H32N2O8 560.6 |
OMOE |
251647-48-0
251647-48-0C41H41N5O8 731.81 |
251647-49-1
251647-49-1C40H41N3O9 707.78 |
1345716-47-3
1345716-47-3C35H39N3O9 645.71 |
182496-01-1
182496-01-1C41H43N3O9 721.81 |
251647-50-4
251647-50-4C38H43N5O9 713.79 |
无登记
无登记C37H42N6O8 698.78 |
163759-50-0
163759-50-0C34H38N2O9 618.68 |
251647-51-5
251647-51-5C33H36N2O9 604.66 |
OH |
81246-82-4
81246-82-4C38H35N5O7 673.73 |
81246-76-6
81246-76-6C37H35N3O8 649.7 |
121058-82-0
121058-82-0C32H33N3O8 587.63 |
160107-17-5
160107-17-5C38H37N3O8 663.73 |
81246-83-5
81246-83-5C35H37N5O8 655.71 |
126922-60-9
126922-60-9C34H36N6O7 640.7 |
138239-62-0
138239-62-0C31H32N2O8 560.6 |
81246-79-9
81246-79-9C30H30N2O8 546.58 |
OTBS |
81265-93-2
81265-93-2C44H49N5O7Si 787.99 |
81256-87-3
81256-87-3C43H49N3O8Si 763.96 |
121058-85-3
121058-85-3C38H47N3O8Si 701.89 |
160107-13-1
160107-13-1C44H51N3O8Si 777.99 |
81279-39-2
81279-39-2C41H51N5O8Si 769.97 |
126922-61-0
126922-61-0C40H50N6O7Si 754.96 |
145784-40-3
145784-40-3C37H46N2O8Si 674.87 |
81246-80-2
81246-80-2C36H44N2O8Si 660.84 |
OC16H33 |
2382942-34-7
2382942-34-7C54H67N5O7 898.16 |
无登记
无登记C53H67N3O8 874.13 |
2382942-37-0
2382942-37-0C48H65N3O8 812.06 |
无登记
无登记C54H69N3O8 888.16 |
2382942-31-4
2382942-31-4C51H69N5O8 880.14 |
无登记
无登记C50H68N6O7 865.13 |
无登记
无登记C47H64N2O8 785.04 |
2382942-76-7
2382942-76-7C46H62N2O8 771.01 |
OPA |
171486-51-4
171486-51-4C41H37N5O7 711.78 |
171486-52-5
171486-52-5C40H37N3O8 687.75 |
1498305-50-2
1498305-50-2C35H35N3O8 625.68 |
无登记
无登记C41H39N3O8 701.78 |
171486-53-6
171486-53-6C38H39N5O8 693.76 |
210096-45-0
210096-45-0C37H38N6O7 678.75 |
860640-56-8
860640-56-8C34H34N2O8 598.65 |
171486-54-7
171486-54-7C33H32N2O8 584.63 |
其他 | 定制 |
Base R | A(Bz) | C(Ac) | G(iBu) | U |
---|---|---|---|---|
OH |
1044505-21-6
1044505-21-6C41H37N5O7 711.78 |
1120329-54-5
1120329-54-5C40H37N3O8 687.75 |
1044505-27-2
1044505-27-2C35H35N3O8 625.68 |
251943-33-6
251943-33-6C41H39N3O8 701.78 |
OBz |
1120329-51-2
1120329-51-2C41H37N5O7 711.78 |
120329-55-6
120329-55-6C40H37N3O8 687.75 |
1120329-60-3
1120329-60-3C35H35N3O8 625.68 |
251943-34-7
251943-34-7C41H39N3O8 701.78 |
其他 | 定制 |
Base R | A(Bz) | meC(Bz) | G(iBu) |
---|---|---|---|
H |
206055-74-5
206055-74-5C39H35N5O7 685.74 |
445012-77-1
445012-77-1C39H37N3O8 675.74 |
206055-72-3
206055-72-3C36H39N5O7 653.74 |
CH3 |
1197033-18-3
1197033-18-3C40H37N5O7 699.76 |
1197033-15-0
1197033-15-0C40H39N3O8 689.77 |
945628-65-9
945628-65-9C37H41N5O7 667.76 |
CN |
无登记
无登记C40H34N6O7 710.75 |
无登记
无登记C41H38N4O7 698.78 |
无登记
无登记C37H38N6O7 678.75 |
其他 | 定制 |