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修饰核苷

核酸单体

递送载体类

核糖

荧光标记类

磷试剂

修饰核苷

核酸单体

递送载体类

核糖

荧光标记类

磷试剂

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骨架 

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UNA
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DNA
LNA

糖修饰 

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CN
CH3
F
OCH3
OMOE
OH
OC16H33
OPA
OPOM
OTBS
H

碱基类型 

C
G
A
meC
U
T
I

骨架 

Others
UNA
RNA
DNA
LNA

糖修饰 

Others
CN
CH3
F
OCH3
OMOE
OH
OC16H33
OPA
OPOM
OTBS
H

碱基类型 

C
G
A
meC
U
T
I

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天然存在的小核酸具有较差的稳定性和非常低的特异性，化学修饰是增强小核苷酸药物成药的有效方法。除了小核酸的磷酸骨架的PS修饰，大多数是在核苷的核糖和碱基的修饰已被广泛采用。将修饰的好的核苷和磷试剂反应做成核酸单体（亚磷酰胺结构），核酸单体按照序列进行小核酸药物的组装。

Base R	A	C	meC	G	T	U	I
H	958-09-8   958-09-8 C₁₀H₁₃N₅O₃ 251.25	951-77-9   951-77-9 C₉H₁₃N₃O₄ 227.22	838-07-3   838-07-3 C₁₀H₁₅N₃O₄ 241.25	961-07-9   961-07-9 C₁₀H₁₃N₅O₄ 267.25	50-89-5   50-89-5 C₁₀H₁₄N₂O₅ 242.23	951-78-0   951-78-0 C₉H₁₂N₂O₅ 228.2	890-38-0   890-38-0 C₁₀H₁₂N₄O₄ 252.23
F	64183-27-3   64183-27-3 C₁₀H₁₂FN₅O₃ 269.24	10212-20-1   10212-20-1 C₉H₁₂FN₃O₄ 245.21	182495-80-3   182495-80-3 C₁₀H₁₄FN₃O₄ 259.24	78842-13-4   78842-13-4 C₁₀H₁₃FN₂O₅ 260.22	122799-38-6   122799-38-6 C₁₀H₁₃FN₂O₅ 260.22	784-71-4   784-71-4 C₉H₁₁FN₂O₅ 246.19	无登记   无登记 C₁₀H₁₁FN₄O₄ 270.22
OCH₃	2140-79-6   2140-79-6 C₁₁H₁₅N₅O₄ 281.27	2140-72-9   2140-72-9 C₁₀H₁₅N₃O₅ 257.25	113886-70-7   113886-70-7 C₁₁H₁₇N₃O₅ 271.27	2140-71-8   2140-71-8 C₁₁H₁₅N₅O₅ 297.27	55486-09-4   55486-09-4 C₁₁H₁₆N₂O₆ 272.26	2140-76-3   2140-76-3 C₁₀H₁₄N₂O₆ 258.23	无登记   无登记 C₁₁H₁₄N₄O₅ 282.26
OMOE	168427-74-5   168427-74-5 C₁₃H₁₉N₅O₅ 325.33	223777-16-0   223777-16-0 C₁₂H₁₉N₃O₆ 301.3	244105-55-3   244105-55-3 C₁₃H₂₁N₃O₆ 315.33	473278-54-5   473278-54-5 C₁₃H₁₉N₅O₆ 341.32	163759-49-7   163759-49-7 C₁₃H₂₀N₂O₇ 316.31	223777-15-9   223777-15-9 C₁₂H₁₈N₂O₇ 302.28	无登记   无登记 C₁₃H₁₈N₄O₆ 326.31
OC₁₆H₃₃	211690-85-6   211690-85-6 C₂₆H₄₅N₅O₄ 491.68	2991498-23-6   2991498-23-6 C₂₅H₄₅N₃O₅ 467.65	无登记   无登记 C₂₆H₄₇N₃O₅ 481.68	2382942-29-0   2382942-29-0 C₂₆H₄₅N₅O₅ 507.68	2991498-24-7   2991498-24-7 C₂₆H₄₆N₂O₆ 482.66	2382942-69-8   2382942-69-8 C₂₅H₄₄N₂O₆ 468.64	无登记   无登记 C₂₆H₄₄N₄O₅ 492.66
OPA	151390-97-5   151390-97-5 C₁₄H₁₉N₅O₄ 321.34	206552-85-4   206552-85-4 C₁₂H₁₅N₃O₅ 281.27	无登记   无登记 C₁₄H₂₁N₃O₅ 311.34	206552-86-5   206552-86-5 C₁₄H₁₉N₅O₅ 337.34	860640-50-2   860640-50-2 C₁₄H₂₀N₂O₆ 312.32	129778-58-1   129778-58-1 C₁₂H₁₄N₂O₆ 282.25	无登记   无登记 C₁₄H₁₈N₄O₅ 322.32
其他	定制

Base R	A	meC	G	T
H	206055-70-1   206055-70-1 C₁₁H₁₃N₅O₄ 279.26	847650-87-7   847650-87-7 C₁₁H₁₅N₃O₅ 269.26	207131-16-6   207131-16-6 C₁₁H₁₃N₅O₅ 295.26	206055-67-6   206055-67-6 C₁₁H₁₄N₂O₆ 270.24
CH₃	1197033-34-3   1197033-34-3 C₁₂H₁₅N₅O₄ 293.28	1197033-37-6   1197033-37-6 C₁₂H₁₇N₃O₅ 283.28	1197033-35-4   1197033-35-4 C₁₂H₁₅N₅O₅ 309.28	1197032-96-4   1197032-96-4 C₁₂H₁₆N₂O₆ 284.27
CN	无登记   无登记 C₁₂H₁₂N₆O₄ 304.27	无登记   无登记 C₁₂H₁₄N₄O₅ 294.27	无登记   无登记 C₁₂H₁₂N₆O₅ 320.27	2404654-10-8   2404654-10-8 C₁₂H₁₃N₃O₆ 295.25
其他	定制

Base R	A(Bz)	C(Bz)	C(Ac)	meC(Bz)	G(iBu)	G(dmf)
H	4546-72-9   4546-72-9 C₁₇H₁₇N₅O₄ 355.35	4836-13-9   4836-13-9 C₁₆H₁₇N₃O₅ 331.33	32909-05-0   32909-05-0 C₁₁H₁₅N₃O₅ 269.26	104579-02-4   104579-02-4 C₁₇H₁₉N₃O₅ 345.36	68892-42-2   68892-42-2 C₁₄H₁₉N₅O₅ 337.34	17331-13-4   17331-13-4 C₁₃H₁₈N₆O₄ 322.33
F	136834-20-3   136834-20-3 C₁₇H₁₆FN₅O₄ 373.34	146954-76-9   146954-76-9 C₁₆H₁₆FN₃O₅ 349.32	159414-97-8   159414-97-8 C₁₁H₁₄FN₃O₅ 287.25	182495-81-4   182495-81-4 C₁₇H₁₈FN₃O₅ 363.35	80681-25-0   80681-25-0 C₁₄H₁₈FN₅O₅ 355.33	无登记   无登记 C₁₃H₁₇FN₆O₄ 340.32
OCH₃	85079-00-1   85079-00-1 C₁₈H₁₉N₅O₅ 385.38	52571-45-6   52571-45-6 C₁₇H₁₉N₃O₆ 361.35	113886-71-8   113886-71-8 C₁₂H₁₇N₃O₆ 299.28	158966-50-8   158966-50-8 C₁₈H₂₁N₃O₆ 375.38	63264-29-9   63264-29-9 C₁₅H₂₁N₅O₆ 367.36	1951424-87-5   1951424-87-5 C₁₄H₂₀N₆O₅ 352.35
OMOE	333335-93-6   333335-93-6 C₂₀H₂₃N₅O₆ 429.43	2305416-18-4   2305416-18-4 C₁₉H₂₃N₃O₇ 405.41	2049081-09-4   2049081-09-4 C₁₄H₂₁N₃O₇ 343.34	340162-93-8   340162-93-8 C₂₀H₂₅N₃O₇ 419.43	440327-50-4   440327-50-4 C₁₇H₂₅N₅O₇ 411.42	无登记   无登记 C₁₆H₂₄N₆O₆ 396.4
OH	4546-55-8   4546-55-8 C₁₇H₁₇N₅O₅ 371.35	13089-48-0   13089-48-0 C₁₆H₁₇N₃O₆ 347.33	3768-18-1   3768-18-1 C₁₁H₁₅N₃O₆ 285.26	160107-15-3   160107-15-3 C₁₇H₁₉N₃O₆ 361.35	64350-24-9   64350-24-9 C₁₄H₁₉N₅O₆ 353.34	1055407-32-3   1055407-32-3 C₁₃H₁₈N₆O₅ 338.32
OC₁₆H₃₃	2382942-33-6   2382942-33-6 C₃₃H₄₉N₅O₅ 595.79	无登记   无登记 C₃₂H₄₉N₃O₆ 571.76	无登记   无登记 C₂₇H₄₇N₃O₆ 509.69	无登记   无登记 C₃₃H₅₁N₃O₆ 585.79	2382942-30-3   2382942-30-3 C₃₀H₅₁N₅O₆ 577.77	无登记   无登记 C₂₉H₅₀N₆O₅ 562.76
OPA	210096-44-9   210096-44-9 C₂₀H₁₉N₅O₅ 409.4	210096-41-6   210096-41-6 C₁₉H₁₉N₃O₆ 385.38	1498305-49-9   1498305-49-9 C₁₄H₁₇N₃O₆ 323.31	无登记   无登记 C₂₀H₂₁N₃O₆ 399.4	2095417-55-1   2095417-55-1 C₁₇H₂₁N₅O₆ 391.38	197151-26-1   197151-26-1 C₁₆H₂₀N₆O₅ 376.37
OPOM	2842847-62-3   2842847-62-3 C₂₃H₂₇N₅O₇ 485.5	无登记   无登记 C₂₂H₂₇N₃O₈ 461.47	无登记   无登记 C₁₇H₂₅N₃O₈ 399.4	无登记   无登记 C₂₃H₂₉N₃O₈ 475.5	无登记   无登记 C₂₀H₂₉N₅O₈ 467.48	无登记   无登记 C₁₉H₂₈N₆O₇ 452.47
其他	定制

Base R	A(Bz)	meC(Bz)	G(iBu)
H	209968-94-5   209968-94-5 C₁₈H₁₇N₅O₅ 383.36	206055-81-4   206055-81-4 C₁₈H₁₉N₃O₆ 373.37	206055-68-7   206055-68-7 C₁₅H₂₁N₅O₅ 351.36
CH₃	1197033-12-7   1197033-12-7 C₁₉H₁₉N₅O₅ 397.39	1197033-07-0   1197033-07-0 C₁₉H₂₁N₃O₆ 387.39	945628-64-8   945628-64-8 C₁₆H₂₃N₅O₅ 365.39
CN	无登记   无登记 C₁₉H₁₆N₆O₅ 406.4	无登记   无登记 C₁₉H₁₈N₄O₆ 396.4	无登记   无登记 C₁₆H₂₀N₆O₅ 374.4
其他	定制

Base R	A(Bz)	C(Bz)	C(Ac)	meC(Bz)	G(iBu)	G(dmf)	T	U
H	64325-78-6   64325-78-6 C₃₈H₃₅N₅O₆ 657.73	67219-55-0   67219-55-0 C₃₇H₃₅N₃O₇ 33.7	100898-63-3   100898-63-3 C₃₂H₃₃N₃O₇ 571.63	104579-03-5   104579-03-5 C₃₈H₃₇N₃O₇ 647.73	68892-41-1   68892-41-1 C₃₅H₃₇N₅O₇ 639.71	40094-22-2   40094-22-2 C₃₄H₃₆N₆O₆ 624.7	40615-39-2   40615-39-2 C₃₁H₃₂N₂O₇ 544.6	23669-79-6   23669-79-6 C₃₀H₃₀N₂O₇ 530.58
F	136834-21-4   136834-21-4 C₃₈H₃₄FN₅O₆ 675.72	146954-77-0   146954-77-0 C₃₇H₃₄FN₃O₇ 651.69	159414-98-9   159414-98-9 C₃₂H₃₂FN₃O₇ 589.62	182495-82-5   182495-82-5 C₃₈H₃₆FN₃O₇ 665.72	144089-96-3   144089-96-3 C₃₅H₃₆FN₅O₇ 657.7	2377586-41-7   2377586-41-7 C₃₄H₃₅FN₆O₆ 642.69	133324-02-4   133324-02-4 C₃₁H₃₁FN₂O₇ 562.59	146954-74-4   146954-74-4 C₃₀H₂₉FN₂O₇ 548.57
OCH₃	110764-72-2   110764-72-2 C₃₉H₃₇N₅O₇ 687.75	110764-74-4   110764-74-4 C₃₈H₃₇N₃O₈ 663.73	199593-08-3   199593-08-3 C₃₃H₃₅N₃O₈ 601.66	741725-57-5   741725-57-5 C₃₉H₃₉N₃O₈ 677.75	114745-26-5   114745-26-5 C₃₆H₃₉N₅O₈ 669.74	1858223-91-2   1858223-91-2 C₃₅H₃₈N₆O₇ 654.72	153631-19-7   153631-19-7 C₃₂H₃₄N₂O₈ 574.63	103285-22-9   103285-22-9 C₃₁H₃₂N₂O₈ 560.6
OMOE	251647-48-0   251647-48-0 C₄₁H₄₁N₅O₈ 731.81	251647-49-1   251647-49-1 C₄₀H₄₁N₃O₉ 707.78	1345716-47-3   1345716-47-3 C₃₅H₃₉N₃O₉ 645.71	182496-01-1   182496-01-1 C₄₁H₄₃N₃O₉ 721.81	251647-50-4   251647-50-4 C₃₈H₄₃N₅O₉ 713.79	无登记   无登记 C₃₇H₄₂N₆O₈ 698.78	163759-50-0   163759-50-0 C₃₄H₃₈N₂O₉ 618.68	251647-51-5   251647-51-5 C₃₃H₃₆N₂O₉ 604.66
OH	81246-82-4   81246-82-4 C₃₈H₃₅N₅O₇ 673.73	81246-76-6   81246-76-6 C₃₇H₃₅N₃O₈ 649.7	121058-82-0   121058-82-0 C₃₂H₃₃N₃O₈ 587.63	160107-17-5   160107-17-5 C₃₈H₃₇N₃O₈ 663.73	81246-83-5   81246-83-5 C₃₅H₃₇N₅O₈ 655.71	126922-60-9   126922-60-9 C₃₄H₃₆N₆O₇ 640.7	138239-62-0   138239-62-0 C₃₁H₃₂N₂O₈ 560.6	81246-79-9   81246-79-9 C₃₀H₃₀N₂O₈ 546.58
OTBS	81265-93-2   81265-93-2 C₄₄H₄₉N₅O₇Si 787.99	81256-87-3   81256-87-3 C₄₃H₄₉N₃O₈Si 763.96	121058-85-3   121058-85-3 C₃₈H₄₇N₃O₈Si 701.89	160107-13-1   160107-13-1 C₄₄H₅₁N₃O₈Si 777.99	81279-39-2   81279-39-2 C₄₁H₅₁N₅O₈Si 769.97	126922-61-0   126922-61-0 C₄₀H₅₀N₆O₇Si 754.96	145784-40-3   145784-40-3 C₃₇H₄₆N₂O₈Si 674.87	81246-80-2   81246-80-2 C₃₆H₄₄N₂O₈Si 660.84
OC₁₆H₃₃	2382942-34-7   2382942-34-7 C₅₄H₆₇N₅O₇ 898.16	无登记   无登记 C₅₃H₆₇N₃O₈ 874.13	2382942-37-0   2382942-37-0 C₄₈H₆₅N₃O₈ 812.06	无登记   无登记 C₅₄H₆₉N₃O₈ 888.16	2382942-31-4   2382942-31-4 C₅₁H₆₉N₅O₈ 880.14	无登记   无登记 C₅₀H₆₈N₆O₇ 865.13	无登记   无登记 C₄₇H₆₄N₂O₈ 785.04	2382942-76-7   2382942-76-7 C₄₆H₆₂N₂O₈ 771.01
OPA	171486-51-4   171486-51-4 C₄₁H₃₇N₅O₇ 711.78	171486-52-5   171486-52-5 C₄₀H₃₇N₃O₈ 687.75	1498305-50-2   1498305-50-2 C₃₅H₃₅N₃O₈ 625.68	无登记   无登记 C₄₁H₃₉N₃O₈ 701.78	171486-53-6   171486-53-6 C₃₈H₃₉N₅O₈ 693.76	210096-45-0   210096-45-0 C₃₇H₃₈N₆O₇ 678.75	860640-56-8   860640-56-8 C₃₄H₃₄N₂O₈ 598.65	171486-54-7   171486-54-7 C₃₃H₃₂N₂O₈ 584.63
其他	定制

Base R	A(Bz)	C(Ac)	G(iBu)	U
OH	1044505-21-6   1044505-21-6 C₄₁H₃₇N₅O₇ 711.78	1120329-54-5   1120329-54-5 C₄₀H₃₇N₃O₈ 687.75	1044505-27-2   1044505-27-2 C₃₅H₃₅N₃O₈ 625.68	251943-33-6   251943-33-6 C₄₁H₃₉N₃O₈ 701.78
OBz	1120329-51-2   1120329-51-2 C₄₁H₃₇N₅O₇ 711.78	120329-55-6   120329-55-6 C₄₀H₃₇N₃O₈ 687.75	1120329-60-3   1120329-60-3 C₃₅H₃₅N₃O₈ 625.68	251943-34-7   251943-34-7 C₄₁H₃₉N₃O₈ 701.78
其他	定制

Base R	A(Bz)	meC(Bz)	G(iBu)
H	206055-74-5   206055-74-5 C₃₉H₃₅N₅O₇ 685.74	445012-77-1   445012-77-1 C₃₉H₃₇N₃O₈ 675.74	206055-72-3   206055-72-3 C₃₆H₃₉N₅O₇ 653.74
CH₃	1197033-18-3   1197033-18-3 C₄₀H₃₇N₅O₇ 699.76	1197033-15-0   1197033-15-0 C₄₀H₃₉N₃O₈ 689.77	945628-65-9   945628-65-9 C₃₇H₄₁N₅O₇ 667.76
CN	无登记   无登记 C₄₀H₃₄N₆O₇ 710.75	无登记   无登记 C₄₁H₃₈N₄O₇ 698.78	无登记   无登记 C₃₇H₃₈N₆O₇ 678.75
其他	定制

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