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骨架
  • Others
  • UNA
  • RNA
  • DNA
  • LNA
糖修饰
  • Others
  • CN
  • CH3
  • F
  • OCH3
  • OMOE
  • OH
  • OC16H33
  • OPA
  • OPOM
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010-52073088
sales@ribio.com

天然存在的小核酸具有较差的稳定性和非常低的特异性,化学修饰是增强小核苷酸药物成药的有效方法。除了小核酸的磷酸骨架的PS修饰,大多数是在核苷的核糖和碱基的修饰已被广泛采用。将修饰的好的核苷和磷试剂反应做成核酸单体(亚磷酰胺结构),核酸单体按照序列进行小核酸药物的组装。

Base R A(Bz) C(Bz) C(Ac) meC(Bz) G(iBu) G(dmf) T U I
H 98796-53-3
98796-53-3

98796-53-3

C48H53N6O7P 856.96

102212-98-6
102212-98-6

102212-98-6

C47H53N4O8P 832.93

154110-40-4
154110-40-4

154110-40-4

C42H51N4O8P 770.86

105931-57-5
105931-57-5

105931-57-5

C48H55N4O8P 846.96

93183-15-4
93183-15-4

93183-15-4

C45H55N6O8P 838.94

330628-04-1
330628-04-1

330628-04-1

C44H54N7O7P 823.93

98796-51-1
98796-51-1

98796-51-1

C41H50N3O8P 743.84

109389-30-2
109389-30-2

109389-30-2

C40H48N3O8P 729.81

141684-35-7
141684-35-7

141684-35-7

C41H48N5O7P 753.84

F 136834-22-5
136834-22-5

136834-22-5

C48H52FN6O7P 874.95

161442-19-9
161442-19-9

161442-19-9

C47H52FN4O8P 850.93

159414-99-0
159414-99-0

159414-99-0

C42H50FN4O8P 788.85

182495-83-6
182495-83-6

182495-83-6

C48H54FN4O8P 864.95

144089-97-4
144089-97-4

144089-97-4

C45H54FN6O8P 856.93

1391913-24-8
1391913-24-8

1391913-24-8

C44H53FN7O7P 841.92

182700-06-7
182700-06-7

182700-06-7

C41H49FN3O8P 761.83

146954-75-8
146954-75-8

146954-75-8

C40H47FN3O8P 747.8

无登记
无登记

无登记

C30H30N2O7 530.58

OCH3 110782-31-5
110782-31-5

110782-31-5

C49H55N6O8P 886.99

110764-78-8
110764-78-8

110764-78-8

C48H55N4O9P 862.96

199593-09-4
199593-09-4

199593-09-4

C43H53N4O9P 800.89

166593-57-3
166593-57-3

166593-57-3

C49H57N4O9P 876.99

150780-67-9
150780-67-9

150780-67-9

C46H57N6O9P 868.97

128219-77-2
128219-77-2

128219-77-2

C45H56N7O8P 853.96

153631-20-0
153631-20-0

153631-20-0

C42H52N3O9P 773.86

110764-79-9
110764-79-9

110764-79-9

C41H50N3O9P 759.84

无登记
无登记

无登记

C42H50N5O8P 783.86

OMOE 251647-53-7
251647-53-7

251647-53-7

C51H59N6O9P 931.04

251647-54-8
251647-54-8

251647-54-8

C50H59N4O10P 907.01

无登记
无登记

无登记

C45H57N4O10P 844.94

163759-94-2
163759-94-2

163759-94-2

C51H61N4O10P 921.04

251647-55-9
251647-55-9

251647-55-9

C48H61N6O10P 913.02

无登记
无登记

无登记

C47H60N7O9P 898.01

163878-63-5
163878-63-5

163878-63-5

C44H56N3O10P 817.92

163759-97-5
163759-97-5

163759-97-5

C43H54N3O10P 803.89

无登记
无登记

无登记

C44H54N5O9P 827.92

OTBS 104992-55-4
104992-55-4

104992-55-4

C54H67N6O8PSi 987.22

118380-84-0
118380-84-0

118380-84-0

C53H67N4O9PSi 963.2

121058-88-6
121058-88-6

121058-88-6

C48H65N4O9PSi 901.13

160107-14-2
160107-14-2

160107-14-2

C54H69N4O9PSi 977.22

147201-04-5
147201-04-5

147201-04-5

C51H69N6O9PSi 969.2

149559-87-5
149559-87-5

149559-87-5

C50H68N7O8PSi 954.19

153631-20-0
153631-20-0

153631-20-0

C47H64N3O9PSi 874.1

118362-03-1
118362-03-1

118362-03-1

C46H62N3O9PSi 860.07

无登记
无登记

无登记

C47H62N5O8PSi 884.1

OC16H33 2382942-35-8
2382942-35-8

2382942-35-8

C64H85N6O8P 1097.39

无登记
无登记

无登记

C63H85N4O9P 1073.37

2382942-38-1
2382942-38-1

2382942-38-1

C58H83N4O9P 1011.29

无登记
无登记

无登记

C64H87N4O9P 1087.39

2382942-32-5
2382942-32-5

2382942-32-5

C61H87N6O9P 1079.37

无登记
无登记

无登记

C60H86N7O8P 1064.36

无登记
无登记

无登记

C57H82N3O9P 984.27

2382942-83-6
2382942-83-6

2382942-83-6

C56H80N3O9P 970.24

无登记
无登记

无登记

C57H80N5O8P 994.27

OPA 171486-59-2
171486-59-2

171486-59-2

C51H55N6O8P 911.01

171486-60-5
171486-60-5

171486-60-5

C50H55N4O9P 886.98

1498305-51-3
1498305-51-3

1498305-51-3

C45H53N4O9P 824.91

无登记
无登记

无登记

C50H56N5O9P 902

171486-61-6
171486-61-6

171486-61-6

C48H57N6O9P 892.99

210096-46-1
210096-46-1

210096-46-1

C47H56N7O8P 877.98

860640-63-7
860640-63-7

860640-63-7

C44H52N3O9P 797.89

171486-62-7
171486-62-7

171486-62-7

C43H50N3O9P 783.86

无登记
无登记

无登记

C44H50N5O8P 807.88

其他 定制
Base R A(Bz) meC(Bz) G(iBu) T
H 206055-79-0
206055-79-0

206055-79-0

C48H52N7O8P 885.96

206055-82-5
206055-82-5

206055-82-5

C48H54N5O9P 875.96

206055-77-8
206055-77-8

206055-77-8

C45H56N7O8P 853.96

206055-75-6
206055-75-6

206055-75-6

C41H49N4O9P 772.84

CH3 1197033-19-4
1197033-19-4

1197033-19-4

C49H54N7O8P 899.99

1197033-17-2
1197033-17-2

1197033-17-2

C49H56N5O9P 889.99

945628-66-0
945628-66-0

945628-66-0

C46H58N7O8P 867.98

1197033-22-9
1197033-22-9

1197033-22-9

C42H51N4O9P 786.86

CN 无登记
无登记

无登记

C49H51N8O8P 910.97

无登记
无登记

无登记

C49H53N6O9P 900.97

无登记
无登记

无登记

C46H55N8O8P 878.97

2404654-12-0
2404654-12-0

2404654-12-0

C42H48N5O9P 797.85

其他 定制
Base R A(Bz) C(Ac) G(iBu) U
OBz 1120329-52-3
1120329-52-3

1120329-52-3

C54H58N7O9P 980.07

1120329-56-7
1120329-56-7

1120329-56-7

C48H56N5O10P 893.97

1120329-61-4
1120329-61-4

1120329-61-4

C51H62N7O9P 948.07

1120329-48-7
1120329-48-7

1120329-48-7

C46H53N4O10P 852.92

其他 定制